منابع مشابه
Metastatic colorectal cancer trials
1 Abad A, Garcia P, Gravalos C, et al. Sequential methotrexate, 5-fluorouracil (5-FU), and high dose leucovorin versus 5-FU and high dose leucovorin versus 5-FU alone for advanced colorectal cancer. A multi-institutional randomized trial. Cancer 1995; 75: 1238–44. 2 Ajani JA, Kanojia MD, Bedikian AY. High-dose methotrexate and 5-fluorouracil in patients with advanced colorectal carcinoma. A ran...
متن کاملClinical trials in cancer.
Randomized controlled trials (RCTs) in cancer are expensive, slow, and often preclude other exploratory investigations that might be valuable. Two types of RCTs should not be conducted. When the results of exploratory studies are so dramatically different from all prior experience, RCTs should be done to improve upon the new finding but not to allocate some patients to inferior control arms to ...
متن کاملPalliative care and cancer trials
Two of the most important concepts in medicine are ‘‘curing’’ and ‘‘caring’’. Patients should enter clinical trials with the understanding that they benefit from the treatment or that there may be some benefit to others. In many cancer trials, for example, the best that can be hoped for is a prolongation of life. Whether or not life is prolonged, we argue that there exists an obligation which c...
متن کاملPalliative care and cancer trials
Two of the most important concepts in medicine are ‘‘curing’’ and ‘‘caring’’. Patients should enter clinical trials with the understanding that they benefit from the treatment or that there may be some benefit to others. In many cancer trials, for example, the best that can be hoped for is a prolongation of life. Whether or not life is prolonged, we argue that there exists an obligation which c...
متن کاملPalliative care and cancer trials
Two of the most important concepts in medicine are ‘‘curing’’ and ‘‘caring’’. Patients should enter clinical trials with the understanding that they benefit from the treatment or that there may be some benefit to others. In many cancer trials, for example, the best that can be hoped for is a prolongation of life. Whether or not life is prolonged, we argue that there exists an obligation which c...
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ژورنال
عنوان ژورنال: Nature
سال: 1994
ISSN: 0028-0836,1476-4687
DOI: 10.1038/370500d0